Applied Therapeutics, Inc. has taken a significant step forward in the treatment of Charcot-Marie-Tooth disease caused by Sorbitol Dehydrogenase deficiency (CMT-SORD), with the presentation of full 12-month clinical results and new topline data from 18 and 24 months at the Peripheral Nerve Society 2025 Annual Meeting. The data underscores the potential of govorestat (AT-007) to alter the course of this rare, progressive neuromuscular disease, offering hope to patients worldwide.

The findings revealed a slowing of disease progression observed via MRI at 24 months, alongside improvements in outcomes and a reduction in sorbitol levels maintained through the same period. Notably, a statistically significant correlation was found between the absolute reduction in sorbitol and changes in the 10MWRT and CMT-FOM Lower Limb domain at 12 months. Although the primary endpoint of 10MWRT at 12 months was not statistically significant, the company has since removed this measure from the CMT-FOM clinical outcomes assessment based on the ACT-CMT study results.

Further bolstering the case for govorestat, treatment in CMT-SORD-Null rats showed a highly statistically significant 37% reduction of sorbitol in the sciatic nerve, mirroring the peripheral neuropathy experienced by patients. The drug has been generally safe and well tolerated, with the company remaining on track for a potential NDA submission in 2025. This commitment reflects Applied Therapeutics' dedication to addressing unmet needs in rare diseases.

The positive data has not gone unnoticed by the investment community, with Applied Therapeutics' shares experiencing a notable surge. Retail traders, in particular, have shown heightened interest, as evidenced by a 629% surge in 24-hour message volume on Stocktwits. The optimism among investors underscores the potential market impact of govorestat, should it receive regulatory approval, marking a pivotal moment for both the company and patients affected by CMT-SORD.

Shed Seven, the Yorkshire Britpop legends, have announced a special one-off summer 2026 performance at Halifax's Piece Hall to celebrate the 30th anniversary of their landmark 1996 album 'A Maximum High'. The band will deliver a full album performance followed by a second set of greatest hits during the Live At The Piece Hall concert series on June 6. This Halifax date will represent Shed Seven's only headline show of summer 2026, making it a particularly significant event for both the band and their dedicated fanbase.

The anniversary concert will feature special guest performances from Seb Lowe and The Guest List, adding to the celebratory atmosphere. Tickets for this exclusive event are scheduled to go on general sale at 10am on Friday, October 24, available through major ticketing platforms including Ticketmaster, Live Nation, and the Piece Hall's official website. The band's return to the Halifax venue follows their previous 2021 performance at the historic courtyard, establishing a continuing relationship with the West Yorkshire location.

'A Maximum High' represented a defining moment in Shed Seven's career, reaching the UK top 10 and selling more than 250,000 copies while spawning five Top 40 singles. Band frontman Rick Witter expressed enthusiasm for the upcoming celebration, stating the band is 'looking forward to giving A Maximum High the birthday party it deserves' and noting particular excitement about 'revisiting some of the songs we haven't played for decades.' The event promises to attract fans from across the country for what organizers describe as a 'one night only' celebratory event.

Shed Seven joins a diverse lineup of artists scheduled for the 2026 Live At The Piece Hall series, including Embrace, Ethel Cain, David Gray, Billy Ocean, Opeth and The Ks. The band's upcoming schedule also includes appearances at the Isle Of Wight Festival in June, featuring headliners Lewis Capaldi, Calvin Harris and The Cure, followed by a supporting performance for Richard Ashcroft at Englefield Estate in Berkshire as part of the Heritage Live series in July. Nicky Chance-Thompson MBE DL, CEO of The Piece Hall Charitable Trust, emphasized the significance of hosting these 'Yorkshire heroes' back at the venue for this milestone celebration.